Bioequivalence of oxymorphone extended release and crush-resistant oxymorphone extended release
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منابع مشابه
Bioequivalence of oxymorphone extended release and crush-resistant oxymorphone extended release
BACKGROUND A formulation of crush-resistant extended-release opioids may deter abuse. The purpose of this study was to evaluate the bioequivalence of oxymorphone extended-release (Oxy-ER) and a crush-resistant formulation of oxymorphone extended-release (Oxy-CRF). METHODS In three open-label, randomized studies, healthy adults at a clinical research center received two single oral doses of Ox...
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The objectives of the study were to determine the pharmacokinetics of oxymorphone (oxy) and of ammonium sulfate-loaded, liposome-encapsulated oxymorphone (LE-ASG oxy) and to evaluate the behavioral effects of both opioid preparations by using ethographic evaluation specific to rhesus monkeys. Rhesus monkeys (n = 8) were injected with 2.0 mg/kg LE-ASG oxy s.c.. Blood samples were collected at se...
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approved in the U.S., and they remain the primary alternatives to oxymorphone ER today. Some pain specialists do not consider LA tramadol (Ultram, PriCara) to be an equivalent alternative to these drugs because of its predominantly nonopioid mechanism of action10 and relatively weak analgesic potency, compared with other more potent opioids. LA hydromorphone (Palladone, Purdue) was withdrawn fr...
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Abstract The main aim of this study was to prepare and evaluate the extended - release system of an anxiolytic substance. Alprazolam is a short-acting benzodiazepine with general properties similar to those of diazepam. Our studies focused on the development of extended drug delivery system based on Hydroxy Propyl Methyl Cellulose (HPMC 4000cps) as retard agent and polyvinylpyrrolidone (PVP k30...
متن کاملA Comparison of Daily Average Consumption Of Oxycodone Controlled Release (OxyContin CR) And Oxymorphone Extended Release (Opana ER) In Patients With Low Back Pain.
OBJECTIVE Our goal was to examine the daily average consumption (DACON) of oxycodone controlled-release tablets (OxyContin CR)and oxymorphone extended-release tablets (Opana ER) in patients with low back pain. STUDY DESIGN An observational, retrospective cohort study enrolled patients with multiple prescriptions for oxycodone CR or oxymorphone ER tablets. These patients also had International...
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ژورنال
عنوان ژورنال: Drug Design, Development and Therapy
سال: 2011
ISSN: 1177-8881
DOI: 10.2147/dddt.s24372